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Glutathione Nasal Spray
A convenient nasal spray formulated with glutathione to support antioxidant defenses, oxidative balance, and everyday cellular wellness.
Hydration Room Rancho Santa Margarita
Physician-founded IV & injection therapy in Rancho Santa Margarita, California. Enjoy privacy and comfort.
HOURS
Mon - Fri: 8:30am-5:30pm
Sat - Sun: 9am-5pm
Closed for lunch 12:30pm-1:30pm every day.
4.9+
Star Patient Rating**
1.5M+
Therapies Delivered
100%
Clinician-Developed Formulas
50+
Hydration Room Locations in California
Visit Our Rancho Santa Margarita Clinic
Phone
Hours
Mon - Fri: 8:30am-5:30pm
Sat - Sun: 9am-5pm
Closed for lunch 12:30pm-1:30pm every day.
Directions
Hydration Room Rancho Santa Margarita is located in Antonio Plaza off Antonio Parkway on the South side of the shopping center, near Pavilions.
Plaza
Antonio Plaza
Parking
Free parking is available anywhere in the Antonio Plaza Shopping Center.
Services Available at Our Rancho Santa Margarita Location
Immunity
Cold & Flu Remedy
From $220
|
Members $165
(Prices vary by location)
Decrease viral symptoms and fatigue, combat dehydration and support the immune system
Immunity
Immune Support
From $220
|
Members $165
(Prices vary by location)
Protect immune system, productivity and maintain peak cellular function
Immunity
Wellness Infusion
From $220
|
Members $165
(Prices vary by location)
Restore and re-energize the immune system when under stress and sleep deprived
Recovery
Fitness Recovery
From $195
|
Members $165
(Prices vary by location)
Improve muscle recovery, prevent lactic acid build up, alleviate acute and chronic pain
Beauty
Skin Health
From $220
|
Members $165
(Prices vary by location)
Hydrate skin from the inside out and receive an all-natural glow
Wellness
Myers Cocktail
From $195
|
Members $165
(Prices vary by location)
Boost immune system, increase energy and overall health and wellness
Recovery
Hangover (Basic)
From $170
|
Members $165
(Prices vary by location)
Reduce dehydration, improve mental recovery and alleviate nausea
Recovery
Hangover (Deluxe)
From $230
|
Members $165
(Prices vary by location)
Reduce dehydration, improve mental recovery and alleviate nausea
Recovery
Jet Lag
From $230
|
Members $165
(Prices vary by location)
Alleviate fogginess, fatigue, dehydration, and reset circadian rhythm
Wellness
Stress Rescue
From $220
|
Members $165
(Prices vary by location)
Relax the mind, increase serotonin/dopamine levels and reduce anxiety
Wellness
Happy Tummy
From $220
|
Members $165
(Prices vary by location)
Reduce bloating, inflammation, abdominal discomfort and malabsorption
Immunity
Glutathione
From $150
(Prices vary by location)
Detoxify the body from reactive oxygen species with this 'Mother' antioxidant
Wellness
Celebration
From $280
|
Members $165
(Prices vary by location)
Improve energy, reduce stress, and provide immune support for an upcoming event
Energy
Energy Boost
From $170
|
Members $165
(Prices vary by location)
Proprietary blend of B vitamins designed to give extra energy and alertness for days
Recovery
GI Cocktail
From $230
|
Members $165
(Prices vary by location)
Helps with dehydration related to vomiting/diarrhea (food poisoning)
Immunity
Vitamin C Boost
From $195
|
Members $165
(Prices vary by location)
A super boost for the immune system to prevent a cold, flu or allergy flare-ups
Wellness
Maternity Wellness
From $220
|
Members $165
(Prices vary by location)
Support healthy amniotic fluid levels, relieve nausea and morning sickness
Wellness
Menopause Relief
From $220
|
Members $165
(Prices vary by location)
Help with symptoms such as fatigue, insomnia, hot flashes, osteoporosis, and vaginal dryness
Recovery
Migraine Relief
From $220
|
Members $165
(Prices vary by location)
Receive ER-level therapy with essential B vitamins that improve associated fatigue and nausea
Wellness
Monthly Relief
From $195
|
Members $165
(Prices vary by location)
Comprehensive IV therapy targeting mood elevation, improved energy and pain control for PMS
Weight Management
Slim
From $220
|
Members $165
(Prices vary by location)
Boost your metabolism, increase energy and your natural ability to break down fat
Weight Management
Skinny Shot Injection
From $50
(Prices vary by location)
Series of 8 injections to kickstart the metabolism and shed unwanted weight
Energy
B12 Basic Boost Injection
From $25
(Prices vary by location)
Reduce fatigue, general sluggishness and increase mental clarity
Immunity
Antioxidant Refresh Shot
From $50
(Prices vary by location)
Boost immune system, maintain heart health and clear toxins
Immunity
Cold and Flu Boost Injection
From $85
(Prices vary by location)
Decrease viral symptoms, increase energy and support immune system
Wellness
Happy Shot
From $50
(Prices vary by location)
Produce more happy neurotransmitters, like serotonin and dopamine
Wellness
Anti-Stress Shot
From $75
(Prices vary by location)
Calm nerve impulses, reduce irritability and emotional fatigue
Immunity
Glutathione Shot
From $99
(Prices vary by location)
Rejuvenate the skin and body from the inside out
Anti-Aging
NAD+ IV
From $549
|
Members $165
(Prices vary by location)
Full replenishment therapy for deep cellular support, energy and clarity
Anti-Aging
NAD+ Injection
From $60
(Prices vary by location)
Quick 5-minute treatment for energy and metabolism support
Anti-Aging
Stem Cells & Exosomes
Advanced regenerative IV therapy for cellular repair and renewal
Wellness
Iron Infusions
Address iron deficiency anemia by restoring your iron levels, combating fatigue and boosting well-being
Weight Management
GLP-1 Injections
Medically-guided weight management, curb appetite and support metabolism goals
Hormone
Testosterone Replacement Therapy (TRT)
Restore testosterone levels to increase energy, muscle mass, focus and mood
Hormone
Hormone Wellness Support
Provider-guided hormone wellness care to address symptoms from hormonal changes
Wellness
Chelation Therapy
Eliminate harmful heavy metals to support cardiovascular health and reduce toxic burden
Three Simple Steps to Feeling Better
Continue Your Wellness Routine at Home
Sprays
NAD+ Nasal Spray
A targeted NAD+ nasal spray designed to support cellular energy, mitochondrial function, and overall wellness.
Sprays
The Cellular Stack
A two-spray wellness stack combining NAD+ and glutathione to support cellular energy, antioxidant balance, and everyday wellness.
Serums
Peptides
GHK-Cu + Snap8 Peptide Serum
A peptide-powered facial serum featuring GHK-Cu and Snap-8, formulated to support smoother, firmer-looking and more youthful skin.
Serums
Night time serum
An overnight facial serum formulated to support skin renewal and hydration while helping promote a smoother, refreshed appearance by morning.
Serums
4-in-1 Serum
A multi-benefit facial serum formulated to support hydration, smoother-looking skin, improved texture, and a refreshed complexion.
No products match your search.
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What to Know Before You Visit Our Rancho Santa Margarita Clinic
-
Bring a valid photo ID
-
Know your goals (energy, immunity, stress, etc.)
-
Provide medical history or list of allergies
-
Wear comfortable clothing
-
Expect a 45–60 min session
Relax in Our Rancho Santa Margarita Wellness Clinic
Our clinic is just minutes from Plaza El Paseo and Central Park, the town center that anchors daily life in Rancho Santa Margarita. It's a clean, modern wellness space designed for comfort and clinical-level care, set in a community built around its trails, its lake, and a strong sense of neighborhood.
Whether you're coming down from a hike at O'Neill Regional Park, wrapping up a round at Tijeras Creek, or unwinding after a night out at the Town Center, our clinic offers a quiet place to slow down and restore. Relax in comfortable seating while our licensed medical team reviews your goals and prepares the IV therapy tailored to you.
An individual treatment room is also available, subject to availability, if you prefer a more private session. You'll receive the same personalized, one-on-one care that Hydration Room is known for across Rancho Santa Margarita.
Whether you're coming down from a hike at O'Neill Regional Park, wrapping up a round at Tijeras Creek, or unwinding after a night out at the Town Center, our clinic offers a quiet place to slow down and restore. Relax in comfortable seating while our licensed medical team reviews your goals and prepares the IV therapy tailored to you.
An individual treatment room is also available, subject to availability, if you prefer a more private session. You'll receive the same personalized, one-on-one care that Hydration Room is known for across Rancho Santa Margarita.
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IV Therapy Membership
Your Monthly Dose of Hydration, Energy & Recovery
Memberships starting at $165/mo
-
1 IV Per Month (Up to $230)
-
20% off Additional IVs, Injections, and Add-Ons
-
Free B12 Shot at Sign Up ($25 Value)
-
Anniversary Award - Free Myers Cocktail IV ($195 Value)
-
Redeem at Any Hydration Room Location
Trusted by Thousands of Patients
The staff was wonderful , professional, kind, and very attentive . I felt comfortable the entire time & truly appreciated the care I received. I would absolutely recommend IV Hydration Room in RSM.
Hydration Room RSM Patient
I love this place. Such a great treatment for your good health! And the nurses are great. Highly recommend it.
Hydration Room RSM Patient
I got the Myers Cocktail IV and I have felt so amazing. The hydration rooms RSM location is one of my favorite.
Hydration Room RSM Patient
Rancho Santa Margarita IV Therapy and Injections
Rancho Santa Margarita's wellness culture blends the active, outdoor lifestyle of Orange County with a growing interest in holistic, preventive, and functional medicine. Between the trails, the lake, and a community that leans into high-tech fitness and recovery, residents here treat wellness as part of daily life. Our physician-formulated IV and injection therapies deliver targeted hydration, vitamins, and essential nutrients directly into the bloodstream to help support the energy and long-term health this pace demands.
Personalized IV and Injection Therapies
Our patients in Rancho Santa Margarita come in with a range of wellness needs. Some are recovering from a workout, others need a reset after a weekend at the lake or a night out, and many are simply managing the stress of a busy family or work schedule. Our licensed medical team takes the time to understand your specific goals and build a therapy around them, whether that's metabolic support, hangover recovery, overall vitality, or a session focused on stress management. View all treatments.How IV and Injection Therapy Works
Oral supplements have to be digested before your body can absorb them. IV therapy delivers hydration and nutrients directly into the bloodstream for faster, more complete absorption. See how they compare below.
|
Factor |
IV Therapy at Hydration Room |
Oral Supplements |
|
Absorption Rates |
Near-complete, directly into the bloodstream |
Estimated 2-20% (gut-dependent) |
|
GI Side Effects |
Bypasses the gut, minimal impact |
Nausea, constipation, and cramping are common |
|
Works With GI Absorption Issues |
Yes, bypasses the gut entirely |
No, depends on gut function |
|
Speed of Delivery |
Immediate entry into the bloodstream |
Slow; digestion and absorption are required |
|
Medical Oversight |
Physician-formulated, team on-site |
Self-administered |
|
Best For |
Guests needing reliable, fast iron replenishment without GI side effects |
Mild ongoing supplementation with good gut health |
Discover Rancho Santa Margarita Hydration Room
Founded in 2014 by Dr. Brett Florie, Board-Certified Anesthesiologist, Hydration Room has been delivering physician-developed IV and injection therapies for over a decade. Our Rancho Santa Margarita clinic, located in Antonio Plaza, uses the same physician-formulated protocols and premium-grade ingredients available at all 50+ Hydration Room locations across California.
We proudly serve residents across Rancho Santa Margarita and the surrounding area, including Mission Viejo, Coto de Caza, Trabuco Canyon, and Las Flores.
Frequently Asked Questions
Our licensed medical team will greet you at Suite A350 in Antonio Plaza on Antonio Parkway. They will review your health history and wellness goals, then confirm or recommend the most appropriate therapy for you.
Most of our IV therapy sessions run 45 to 60 minutes, depending on the therapy you select.
Yes! Every IV therapy session is administered by trained nurses using medical-grade equipment in our clinic. Your safety and comfort are monitored throughout your entire visit.
We do not bill insurance directly, but many vitamin IV therapies qualify for FSA or HSA reimbursement. We recommend confirming eligibility with your plan administrator before your visit.
Yes! You are welcome to bring a friend or family member. Many of our local guests find that sharing the experience makes the session more relaxing.
Bring a valid photo ID and wear comfortable clothing with easy sleeve access. If it is your first session with us, we recommend arriving a few minutes early to complete a short intake form. You are also welcome to bring a light blanket, headphones, or something to read.
Yes, Hydration Room offers mobile IV therapy services at select locations across Orange County. Whether you need a session at home, at the office, or at a group event in the area, we can come to you with convenient, on-demand care.
Get Started Today
Ready to Feel Your Best?
Don't miss your chance to experience personalized vitamin
injection therapy or IV hydration at Hydration Room Rancho Santa Margarita!
injection therapy or IV hydration at Hydration Room Rancho Santa Margarita!