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Hydration Room Rancho Santa Margarita clinic

Hydration Room Rancho Santa Margarita

Physician-founded IV & injection therapy in Rancho Santa Margarita, California. Enjoy privacy and comfort.
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4.9+
Star Patient Rating**
1.5M+
Therapies Delivered
100%
Clinician-Developed Formulas
50+
Hydration Room Locations in California

Visit Our Rancho Santa Margarita Clinic

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Hours

Mon - Sun: 8:00am-8:00pm

Directions

Hydration Room Rancho Santa Margarita is located in Antonio Plaza off Antonio Parkway on the South side of the shopping center, near Pavilions.

Plaza

Antonio Plaza

Parking

Free parking is available anywhere in the Antonio Plaza Shopping Center.  

Services Available at Our Rancho Santa Margarita Location

Immunity

Cold & Flu Remedy

Decrease viral symptoms and fatigue, combat dehydration and support the immune system
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Immunity

Immune Support

Protect immune system, productivity and maintain peak cellular function
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Immunity

Wellness Infusion

Restore and re-energize the immune system when under stress and sleep deprived
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Recovery

Fitness Recovery

Improve muscle recovery, prevent lactic acid build up, alleviate acute and chronic pain
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Beauty

Skin Health

Hydrate skin from the inside out and receive an all-natural glow
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Wellness

Myers Cocktail

Boost immune system, increase energy and overall health and wellness
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Recovery

Hangover (Basic)

Reduce dehydration, improve mental recovery and alleviate nausea
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Recovery

Hangover (Deluxe)

Reduce dehydration, improve mental recovery and alleviate nausea
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Recovery

Jet Lag

Alleviate fogginess, fatigue, dehydration, and reset circadian rhythm
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Wellness

Stress Rescue

Relax the mind, increase serotonin/dopamine levels and reduce anxiety
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Wellness

Happy Tummy

Reduce bloating, inflammation, abdominal discomfort and malabsorption
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Immunity

Glutathione

Detoxify the body from reactive oxygen species with this 'Mother' antioxidant
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Wellness

Celebration

Improve energy, reduce stress, and provide immune support for an upcoming event
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Energy

Energy Boost

Proprietary blend of B vitamins designed to give extra energy and alertness for days
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Recovery

GI Cocktail

Helps with dehydration related to vomiting/diarrhea (food poisoning)
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Immunity

Vitamin C Boost

A super boost for the immune system to prevent a cold, flu or allergy flare-ups
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Wellness

Maternity Wellness

Support healthy amniotic fluid levels, relieve nausea and morning sickness
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Wellness

Menopause Relief

Help with symptoms such as fatigue, insomnia, hot flashes, osteoporosis, and vaginal dryness
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Recovery

Migraine Relief

Receive ER-level therapy with essential B vitamins that improve associated fatigue and nausea
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Wellness

Monthly Relief

Comprehensive IV therapy targeting mood elevation, improved energy and pain control for PMS
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Weight Management

Slim

Boost your metabolism, increase energy and your natural ability to break down fat
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Weight Management

Skinny Shot Injection

Series of 8 injections to kickstart the metabolism and shed unwanted weight
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Energy

B12 Basic Boost Injection

Reduce fatigue, general sluggishness and increase mental clarity
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Immunity

Antioxidant Refresh Shot

Boost immune system, maintain heart health and clear toxins
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Immunity

Cold and Flu Boost Injection

Decrease viral symptoms, increase energy and support immune system
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Wellness

Happy Shot

Produce more happy neurotransmitters, like serotonin and dopamine
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Wellness

Anti-Stress Shot

Calm nerve impulses, reduce irritability and emotional fatigue
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Immunity

Glutathione Shot

Rejuvenate the skin and body from the inside out
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Anti-Aging

NAD+ IV

Full replenishment therapy for deep cellular support, energy and clarity
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Anti-Aging

NAD+ Injection

Quick 5-minute treatment for energy and metabolism support
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Anti-Aging

NAD+ Nasal Spray

On-the-go option for mood, focus, and travel convenience
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Anti-Aging

Stem Cells & Exosomes

Advanced regenerative IV therapy for cellular repair and renewal
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Wellness

Iron Infusions

Address iron deficiency anemia by restoring your iron levels, combating fatigue and boosting well-being
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Weight Management

GLP-1 Injections

Medically-guided weight management — curb appetite and support metabolism goals
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Hormone

Testosterone Replacement Therapy (TRT)

Restore testosterone levels to increase energy, muscle mass, focus and mood
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Hormone

Hormone Wellness Support

Provider-guided hormone wellness care to address symptoms from hormonal changes
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Wellness

Chelation Therapy

Eliminate harmful heavy metals to support cardiovascular health and reduce toxic burden
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Three Simple Steps to Feeling Better

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1

Book Your Appointment

Schedule online or call us.
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2

Confirm Your Therapy

Not sure what you need? Our licensed medical team will help confirm or adjust your therapy at your appointment.
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3

Feel Refreshed & Restored

Feel renewed with immune support and refreshed hydration.
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What To Know Before You Visit

  • Bring photo ID
  • Know your goals (energy, immunity, stress, etc.)
  • Provide medical history or list of allergies
  • Wear comfortable clothing
  • Expect a 45–60 min session

Relax in Our Rancho Santa Margarita Wellness Clinic

Experience a modern wellness environment designed for comfort and clinical-level care. Our Rancho Santa Margarita, CA Hydration Room clinic blends a calming atmosphere with a professional, medically guided IV therapy experience from the moment you walk in.

Relax in comfortable seating while our licensed medical team prepares your customized IV therapy. The space is intentionally quiet and soothing, allowing you to unwind while receiving high-quality vitamins and hydration.

If you prefer a more private visit, our individual treatment rooms provide a peaceful, uninterrupted setting for your IV infusion. Settle in, get cozy, and enjoy a personalized wellness experience tailored to your needs—right here in the heart of Rancho Santa Margarita.
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Trusted by Thousands of Patients

The place is really clean,
staff is great and process
took about 1 hour.
Anne S.
Hydration room stands out
far and above the rest.
Russ T.
A day after it has exceeded
my expectations
Andreas H.

Frequently Asked Questions

You’ll meet with a licensed medical professional who reviews your health goals and recommends the best IV therapy for your needs.
Most IV hydration therapy sessions last 45–60 minutes, depending on your selected therapy.
Yes! Every IV vitamin treatment is administered by trained nurses using medical-grade equipment in our IV therapy clinic. Your safety is our top priority.
We don’t bill insurance directly, but most of our vitamin infusion treatments qualify for FSA or HSA reimbursement.

Absolutely! If you’re feeling nervous or just want some company, you’re welcome to bring a friend or family member. Many patients find the experience more relaxing with a loved one beside them.

Just bring a valid photo ID and wear comfortable clothing that allows easy access to your arm for the IV drip. Arrive a few minutes early if it’s your first visit to complete a short intake form. You're also welcome to bring water, light blanket, headphones, or a book while you receive your hydration drip therapy.
Yes. Hydration Room offers convenient mobile IV therapy services at select locations. Whether you need IV drip at home, in your office, or hotel, we come to you. However, please note that our BOGO offer is valid for in-clinic treatments only.

Rancho Santa Margarita IV Therapy and Injections

Recharge, Hydrate, and Thrive. Need a refresh? Hydration Room’s IV therapy and vitamin injections deliver hydration, essential nutrients, and antioxidants directly into your system for optimal wellness. If you're looking to strengthen immunity, support workout recovery, or improve mental clarity, our customized treatments will help you feel your best. Visit us in Rancho Santa Margarita, CA.

Our IV and Injection Therapies

At Hydration Room, we offer physician-designed IV and injection therapies tailored to your unique health and wellness goals. Whether you need relief from migraines, jet lag, inflammation, or chronic fatigue, our targeted IV treatments are designed for rapid absorption and long-lasting benefits—so you can get back to doing what you love. View all Services.

Premier IV and Injection Therapies in Rancho Santa Margarita

Since 2014, Hydration Room has led the way in modern IV therapy, offering treatments that promote hydration, energy, and long-term wellness. Our proprietary IV formulas support immune function, metabolism, and recovery, making it easier to maintain peak health. With both in-clinic and mobile IV therapy services, we bring physician-designed wellness to Rancho Santa Margarita and surrounding areas

How IV Therapy Works

IV therapy is an efficient, effective way to restore hydration and replenish key nutrients that your body needs to function optimally. Unlike oral supplements, which take time to absorb, IV therapy delivers vitamins and minerals directly into the bloodstream for fast-acting results.

At our Rancho Santa Margarita location, our medical professionals ensure a relaxing, spa-like experience where you can unwind while recharging your body.

High-Quality Formulas, Backed by Science

Hydration Room’s IV and injection therapies are physician-developed and made with premium, pharmacy-grade ingredients. From immune-boosting antioxidants to metabolism-enhancing nutrients, our treatments are designed for maximum effectiveness and long-term wellness benefits.

Mobile IV Therapy in Rancho Santa Margarita – Wellness on the Go

Want IV therapy without leaving your home? Hydration Room offers mobile IV therapy in Rancho Santa Margarita, bringing hydration, recovery, and wellness support right to your doorstep. Whether you're at home, at work, or hosting an event, our mobile services ensure convenient, on-demand care when you need it most.

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Ready to Feel Your Best?

Don’t miss your chance to experience personalized vitamin
injection therapy or IV hydration at Hydration Room!
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